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MAJOR DEPRESSIVE DISORDER, INCREASED RECURRENCE OF DEPRESSIVE EPISODES IN, SUSCEPTIBILITY TO

MedGen UID:
865238
•Concept ID:
C4016801
•
Finding
OMIM®: 602623

Professional guidelines

PubMed

Exploring the genetic heterogeneity in major depression across diagnostic criteria.
Jermy BS, Glanville KP, Coleman JRI, Lewis CM, Vassos E
Mol Psychiatry 2021 Dec;26(12):7337-7345. Epub 2021 Jul 21 doi: 10.1038/s41380-021-01231-w. PMID: 34290369Free PMC Article
Can long-term treatment with antidepressant drugs worsen the course of depression?
Fava GA
J Clin Psychiatry 2003 Feb;64(2):123-33. doi: 10.4088/jcp.v64n0204. PMID: 12633120

Recent clinical studies

Etiology

Predictors of recurrence of major depressive disorder.
Lye MS, Tey YY, Tor YS, Shahabudin AF, Ibrahim N, Ling KH, Stanslas J, Loh SP, Rosli R, Lokman KA, Badamasi IM, Faris-Aldoghachi A, Abdul Razak NA
PLoS One 2020;15(3):e0230363. Epub 2020 Mar 19 doi: 10.1371/journal.pone.0230363. PMID: 32191745Free PMC Article
Exome sequencing in large, multiplex bipolar disorder families from Cuba.
Maaser A, Forstner AJ, Strohmaier J, Hecker J, Ludwig KU, Sivalingam S, Streit F, Degenhardt F, Witt SH, Reinbold CS, Koller AC, Raff R, Heilmann-Heimbach S, Fischer SB; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Herms S, Hoffmann P, Thiele H, Nürnberg P, Löhlein Fier H, Orozco-Díaz G, Carmenate-Naranjo D, Proenza-Barzaga N, Auburger GWJ, Andlauer TFM, Cichon S, Marcheco-Teruel B, Mors O, Rietschel M, Nöthen MM
PLoS One 2018;13(10):e0205895. Epub 2018 Oct 31 doi: 10.1371/journal.pone.0205895. PMID: 30379966Free PMC Article
Impact of depressive episodes on cognitive deficits in early bipolar disorder: data from the Systematic Treatment Optimization Programme for Early Mania (STOP-EM).
Muralidharan K, Torres IJ, Silveira LE, Kozicky JM, Bücker J, Fernando N, Yatham LN
Br J Psychiatry 2014 Jul;205(1):36-43. Epub 2014 Apr 24 doi: 10.1192/bjp.bp.113.135525. PMID: 24764544
Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression.
Li Y, Shi S, Yang F, Gao J, Li Y, Tao M, Wang G, Zhang K, Gao C, Liu L, Li K, Li K, Liu Y, Wang X, Zhang J, Lv L, Wang X, Chen Q, Hu J, Sun L, Shi J, Chen Y, Xie D, Flint J, Kendler KS, Zhang Z
Psychol Med 2012 Jun;42(6):1239-48. Epub 2011 Nov 30 doi: 10.1017/S003329171100273X. PMID: 22126712Free PMC Article
Family-based association of FKBP5 in bipolar disorder.
Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS, Zandi PP, Lee RS, MacKinnon DF, Mondimore FM, Schweizer B; Bipolar Disorder Phenome Group; NIMH Genetics Initiative Bipolar Disorder Consortium, DePaulo JR Jr, Gershon ES, McMahon FJ, Potash JB
Mol Psychiatry 2009 Mar;14(3):261-8. Epub 2008 Jan 8 doi: 10.1038/sj.mp.4002141. PMID: 18180755Free PMC Article

Diagnosis

Exploring the genetic heterogeneity in major depression across diagnostic criteria.
Jermy BS, Glanville KP, Coleman JRI, Lewis CM, Vassos E
Mol Psychiatry 2021 Dec;26(12):7337-7345. Epub 2021 Jul 21 doi: 10.1038/s41380-021-01231-w. PMID: 34290369Free PMC Article
Predictors of recurrence of major depressive disorder.
Lye MS, Tey YY, Tor YS, Shahabudin AF, Ibrahim N, Ling KH, Stanslas J, Loh SP, Rosli R, Lokman KA, Badamasi IM, Faris-Aldoghachi A, Abdul Razak NA
PLoS One 2020;15(3):e0230363. Epub 2020 Mar 19 doi: 10.1371/journal.pone.0230363. PMID: 32191745Free PMC Article
Exome sequencing in large, multiplex bipolar disorder families from Cuba.
Maaser A, Forstner AJ, Strohmaier J, Hecker J, Ludwig KU, Sivalingam S, Streit F, Degenhardt F, Witt SH, Reinbold CS, Koller AC, Raff R, Heilmann-Heimbach S, Fischer SB; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Herms S, Hoffmann P, Thiele H, Nürnberg P, Löhlein Fier H, Orozco-Díaz G, Carmenate-Naranjo D, Proenza-Barzaga N, Auburger GWJ, Andlauer TFM, Cichon S, Marcheco-Teruel B, Mors O, Rietschel M, Nöthen MM
PLoS One 2018;13(10):e0205895. Epub 2018 Oct 31 doi: 10.1371/journal.pone.0205895. PMID: 30379966Free PMC Article
The importance of TCF4 gene in the etiology of recurrent depressive disorders.
Mossakowska-Wójcik J, Orzechowska A, Talarowska M, Szemraj J, Gałecki P
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jan 3;80(Pt C):304-308. Epub 2017 Mar 21 doi: 10.1016/j.pnpbp.2017.03.014. PMID: 28341444
Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression.
Li Y, Shi S, Yang F, Gao J, Li Y, Tao M, Wang G, Zhang K, Gao C, Liu L, Li K, Li K, Liu Y, Wang X, Zhang J, Lv L, Wang X, Chen Q, Hu J, Sun L, Shi J, Chen Y, Xie D, Flint J, Kendler KS, Zhang Z
Psychol Med 2012 Jun;42(6):1239-48. Epub 2011 Nov 30 doi: 10.1017/S003329171100273X. PMID: 22126712Free PMC Article

Therapy

Do anxiety symptoms predict major depressive disorder in midlife women? The Study of Women's Health Across the Nation (SWAN) Mental Health Study (MHS).
Kravitz HM, Schott LL, Joffe H, Cyranowski JM, Bromberger JT
Psychol Med 2014 Sep;44(12):2593-602. Epub 2014 Jan 27 doi: 10.1017/S0033291714000075. PMID: 24467997Free PMC Article
Can long-term treatment with antidepressant drugs worsen the course of depression?
Fava GA
J Clin Psychiatry 2003 Feb;64(2):123-33. doi: 10.4088/jcp.v64n0204. PMID: 12633120
The interplay and etiological continuity of neuroticism, difficulties, and life events in the etiology of major and subsyndromal, first and recurrent depressive episodes in later life.
Ormel J, Oldehinkel AJ, Brilman EI
Am J Psychiatry 2001 Jun;158(6):885-91. doi: 10.1176/appi.ajp.158.6.885. PMID: 11384895
Depression and weight gain: the serotonin connection.
Wurtman JJ
J Affect Disord 1993 Oct-Nov;29(2-3):183-92. doi: 10.1016/0165-0327(93)90032-f. PMID: 8300977
Long-term administration of tianeptine in depressed patients after alcohol withdrawal.
Malka R, Lôo H, Ganry H, Souche A, Marey C, Kamoun A
Br J Psychiatry Suppl 1992 Feb;(15):66-71. PMID: 1389025

Prognosis

Predictors of recurrence of major depressive disorder.
Lye MS, Tey YY, Tor YS, Shahabudin AF, Ibrahim N, Ling KH, Stanslas J, Loh SP, Rosli R, Lokman KA, Badamasi IM, Faris-Aldoghachi A, Abdul Razak NA
PLoS One 2020;15(3):e0230363. Epub 2020 Mar 19 doi: 10.1371/journal.pone.0230363. PMID: 32191745Free PMC Article
Temporal Structure of Mixed States: Does Sensitization Link Life Course to Episodes?
Swann AC, Lijffijt M, Simonetti A
Psychiatr Clin North Am 2020 Mar;43(1):153-165. Epub 2019 Nov 28 doi: 10.1016/j.psc.2019.10.005. PMID: 32008682
Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways.
Anderson G, Jacob A, Bellivier F, Geoffroy PA
Curr Pharm Des 2016;22(8):987-1012. doi: 10.2174/1381612822666151214105314. PMID: 26654772
Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression.
Li Y, Shi S, Yang F, Gao J, Li Y, Tao M, Wang G, Zhang K, Gao C, Liu L, Li K, Li K, Liu Y, Wang X, Zhang J, Lv L, Wang X, Chen Q, Hu J, Sun L, Shi J, Chen Y, Xie D, Flint J, Kendler KS, Zhang Z
Psychol Med 2012 Jun;42(6):1239-48. Epub 2011 Nov 30 doi: 10.1017/S003329171100273X. PMID: 22126712Free PMC Article
Can long-term treatment with antidepressant drugs worsen the course of depression?
Fava GA
J Clin Psychiatry 2003 Feb;64(2):123-33. doi: 10.4088/jcp.v64n0204. PMID: 12633120

Clinical prediction guides

Predictors of recurrence of major depressive disorder.
Lye MS, Tey YY, Tor YS, Shahabudin AF, Ibrahim N, Ling KH, Stanslas J, Loh SP, Rosli R, Lokman KA, Badamasi IM, Faris-Aldoghachi A, Abdul Razak NA
PLoS One 2020;15(3):e0230363. Epub 2020 Mar 19 doi: 10.1371/journal.pone.0230363. PMID: 32191745Free PMC Article
Exome sequencing in large, multiplex bipolar disorder families from Cuba.
Maaser A, Forstner AJ, Strohmaier J, Hecker J, Ludwig KU, Sivalingam S, Streit F, Degenhardt F, Witt SH, Reinbold CS, Koller AC, Raff R, Heilmann-Heimbach S, Fischer SB; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Herms S, Hoffmann P, Thiele H, Nürnberg P, Löhlein Fier H, Orozco-Díaz G, Carmenate-Naranjo D, Proenza-Barzaga N, Auburger GWJ, Andlauer TFM, Cichon S, Marcheco-Teruel B, Mors O, Rietschel M, Nöthen MM
PLoS One 2018;13(10):e0205895. Epub 2018 Oct 31 doi: 10.1371/journal.pone.0205895. PMID: 30379966Free PMC Article
Investigating the genetic variation underlying episodicity in major depressive disorder: suggestive evidence for a bipolar contribution.
Ferentinos P, Rivera M, Ising M, Spain SL, Cohen-Woods S, Butler AW, Craddock N, Owen MJ, Korszun A, Jones L, Jones I, Gill M, Rice JP, Maier W, Mors O, Rietschel M, Lucae S, Binder EB, Preisig M, Tozzi F, Muglia P, Breen G, Craig IW, Farmer AE, Müller-Myhsok B, McGuffin P, Lewis CM
J Affect Disord 2014 Feb;155:81-9. Epub 2013 Oct 29 doi: 10.1016/j.jad.2013.10.027. PMID: 24215895
Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression.
Li Y, Shi S, Yang F, Gao J, Li Y, Tao M, Wang G, Zhang K, Gao C, Liu L, Li K, Li K, Liu Y, Wang X, Zhang J, Lv L, Wang X, Chen Q, Hu J, Sun L, Shi J, Chen Y, Xie D, Flint J, Kendler KS, Zhang Z
Psychol Med 2012 Jun;42(6):1239-48. Epub 2011 Nov 30 doi: 10.1017/S003329171100273X. PMID: 22126712Free PMC Article
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
O'Leary JC 3rd, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA
PLoS One 2011;6(9):e24840. Epub 2011 Sep 15 doi: 10.1371/journal.pone.0024840. PMID: 21935478Free PMC Article

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